Best for · longevity
Longevity & Cognitive Aging
Longevity-focused protocols target mitochondrial support (CoQ10, PQQ, NR/NMN), membrane integrity (Omega-3, phosphatidylserine), and emerging senolytics (fisetin, quercetin). Effects compound over years, not weeks.
Ranked substances
| # | Substance | Category | Typical dose | Evidence | Safety | In stacks |
|---|---|---|---|---|---|---|
| 1 | Nicotinamide Riboside (NR) | neuroprotective | 250–1000mg | EVIDENCEA | ●●●●● | 2 |
| 2 | Omega-3 (DHA/EPA) | neuroprotective | 1000–3000mg | EVIDENCEA | ●●●●● | 2 |
| 3 | Alpha-Lipoic Acid | neuroprotective | 300–600mg | EVIDENCEA | ●●●●○ | 2 |
| 4 | CoQ10 | neuroprotective | 100–300mg | EVIDENCEA | ●●●●● | 1 |
| 5 | Creatine | amino-acid | 3000–5000mg | EVIDENCEA | ●●●●● | 1 |
| 6 | Vitamin D3 | vitamin | 0.025–0.125mg | EVIDENCEA | ●●●●● | 1 |
| 7 | Curcumin (Turmeric) | neuroprotective | 500–2000mg | EVIDENCEB | ●●●●● | 1 |
| 8 | Magnesium L-Threonate | neuroprotective | 1000–2000mg | EVIDENCEB | ●●●●● | 1 |
| 9 | Pterostilbene | neuroprotective | 50–250mg | EVIDENCEB | ●●●●● | 1 |
| 10 | Resveratrol | neuroprotective | 250–500mg | EVIDENCEB | ●●●●● | 1 |
| 11 | Taurine | amino-acid | 1000–3000mg | EVIDENCEB | ●●●●● | 1 |
Curated stacks for longevity
advanced
Longevity Brain Stack
Protect mitochondrial function, reduce neuroinflammation, support long-term brain health.
$4.80/dayOpen
intermediateAnti-Aging Brain Stack
Antioxidant and methylation support for brain longevity. Lower-cost approach than NMN/NR.
$2.80/dayOpen
advancedNAD+ Longevity Stack
NAD+ precursor protocol for cellular age-reversal research. Pair NR/NMN with sirtuin activators.
$5.40/dayOpen
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