Comparison
Resveratrol vs Pterostilbene
Resveratrol
Polyphenol from grape skins and Japanese knotweed. SIRT1 activator. Studied for longevity and cardiovascular health.
Pterostilbene
Methylated analog of resveratrol with much higher bioavailability. Found in blueberries.
| Field | Resveratrol | Pterostilbene |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 250–500mg | 50–250mg |
| Half-life | 9h | – |
| Onset | – | – |
| Evidence | EVIDENCEB | EVIDENCEB |
| Safety | ●●●●● | ●●●●● |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 16000 | 280 |
The comparison in plain English
Two polyphenols that activate SIRT1 (a sirtuin associated with longevity). Resveratrol is the more famous one (from red wine). Pterostilbene is the methylated analog found in blueberries, it has 4x the bioavailability and a longer half-life.
Bottom line
Pterostilbene is the more practical molecule by bioavailability. Resveratrol has the larger evidence base and the cardiovascular trials. They are routinely stacked (Elysium Basis uses both).
Choose Resveratrol if
You want the better-evidenced cardiovascular benefit. 250–500mg with fat.
Choose Pterostilbene if
You want better bioavailability per dose. 50–250mg AM. Can mildly raise LDL at the top of the range.