Comparison
Fisetin vs Quercetin
Fisetin
Flavonoid found in strawberries. Senolytic, selectively clears senescent cells. Promising longevity intervention.
Quercetin
Flavonoid found in onions, apples, capers. Senolytic (especially with dasatinib), antiviral, anti-inflammatory.
| Field | Fisetin | Quercetin |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 100–500mg | 250–1000mg |
| Half-life | – | – |
| Onset | – | – |
| Evidence | EVIDENCEB | EVIDENCEB |
| Safety | ●●●●○ | ●●●●○ |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 1700 | 4600 |
The comparison in plain English
Two flavonoid senolytics, compounds that selectively clear senescent cells. Fisetin (from strawberries) has emerged as the most potent natural senolytic. Quercetin (from onions, apples) is more researched and is the senolytic typically paired with dasatinib in human trials.
Bottom line
Fisetin is the more potent natural senolytic monotherapy and is taken in short intermittent protocols (e.g. 1–2 days/month at 1000mg). Quercetin is the better-studied multi-purpose flavonoid with cardiovascular and antiviral benefits beyond senolysis.
Choose Fisetin if
Your specific goal is senolytic intervention. 100–500mg in short pulses.
Choose Quercetin if
You want broader cardiovascular and antiviral benefits with some senolytic effect. 250–1000mg with food. Phytosome forms are more bioavailable.