vitaminEVIDENCEAUSOTC
Vitamin B12
aka Methylcobalamin · Cyanocobalamin · Cobalamin
Methylcobalamin / cyanocobalamin. Essential for myelin, neurotransmitter synthesis, and methylation. Vegetarians often deficient.
Dose range0.5–5mg
Half-life—h
Onset—min
Safety5/5high evidence base
Mechanism of action
Cofactor in methionine synthase (folate-methionine cycle) and methylmalonyl-CoA mutase. Required for myelin synthesis.
Benefits
Cognitive function (when deficient)
EVIDENCEAMultiple RCTs in deficient subjects.
Energy / fatigue (when deficient)
EVIDENCEAUniversally accepted.
Side effects
- Very rare allergic reactionsraremild
Where to buy
Affiliate linksNo vendor products listed yet. Vendors — list a product.