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neuroprotectiveEVIDENCEBUSBannedBanned: US (FDA dietary supplement ban 2019)

Vinpocetine

aka Cavinton

Semi-synthetic derivative of vincamine from periwinkle. Increases cerebral blood flow.

Dose range5–30mg
Half-life2h
Onsetmin
Safety4/5medium evidence base

Mechanism of action

Inhibits PDE1, increasing cGMP and cerebral blood flow. Sodium channel blocker. Antioxidant.

Benefits

  • Cerebrovascular insufficiency

    EVIDENCEB

    European prescription use.

  • Cognitive function in vascular dementia

    EVIDENCEB

    Multiple RCTs.

Side effects

  • Mild blood pressure decreasecommonmild
  • GI upsetuncommonmild

Where to buy

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