neuroprotectiveEVIDENCEBUSOTC

Urolithin A (Mitopure)

aka Mitopure · UA

Bioactive metabolite of pomegranate ellagitannins. Direct mitophagy activator. The supplement form bypasses the gut microbiome variability.

Dose range500–1000mg

Half-life—h

Onset—min

Safety5/5medium evidence base

Mechanism of action

Selectively activates mitophagy — the autophagy of damaged mitochondria — through PINK1/Parkin signaling. The mechanism is similar in effect to caloric restriction or exercise's mitochondrial benefits. Only about 40% of humans produce urolithin A from dietary precursors due to gut microbiome variation; direct supplementation bypasses this issue.

History

Urolithin A was identified as the bioactive gut microbiome metabolite of pomegranate ellagitannins in the 2000s. Amazentis (a Swiss company) developed a manufacturing process for synthetic urolithin A and launched Mitopure in 2020. Andreux 2019 demonstrated muscle function improvement in older adults. The compound represents a new class of mitochondrial-targeting supplements with stronger evidence than pomegranate extract for the mitochondrial effects.

Benefits

Mitophagy activation
EVIDENCEB
Andreux 2019, Liu 2022.
Muscle function in older adults
EVIDENCEB
Liu 2022.
Endurance and exercise performance
EVIDENCEB
Singh 2022.

Side effects

Mild GI upsetraremild

Cited research

Urolithin A safety and pharmacokinetics in humans (Andreux)2019
PMID 31322110 ↗
Urolithin A for muscle function in older adults (Liu)2022
PMID 35672418 ↗
Urolithin A and mitochondrial function review (D'Amico)2021
PMID 33358850 ↗

Where to buy

Affiliate links

Ad Affiliate links — we may earn a commission at no extra cost to you.

Vendor	Product	Size	Price	Per unit
Nootropics DepotFeatured 4.8	Urolithin A (Mitopure) — Nootropics Depot	—	See vendor	—	Shop Ad
Life Extension 4.3	Urolithin A (Mitopure) — Life Extension	—	See vendor	—	Shop Ad
Tru Niagen (ChromaDex) 4.4	Urolithin A (Mitopure) — Tru Niagen	—	See vendor	—	Shop Ad
DoNotAge 4.4	Urolithin A (Mitopure) — DoNotAge	—	See vendor	—	Shop Ad
Amazon Marketplace 3.5	Urolithin A (Mitopure) — Amazon	—	See vendor	—	Shop Ad

Community reviews

0 approved

No approved reviews yet. Be the first.

Share your experience

Reviews require disclosed dose, duration, and conflict of interest. Posted after editorial review.