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stimulantEVIDENCEBUSOTC

Theacrine

aka 1,3,7,9-tetramethyluric acid · TeaCrine

Methylated purine alkaloid related to caffeine. Slower onset, longer duration, no tolerance.

Dose range100–300mg
Half-life17h
Onset—min
Safety4/5medium evidence base

Mechanism of action

Adenosine A1/A2A antagonist (like caffeine) plus weak dopamine reuptake inhibition. No habituation seen at 8 weeks.

Benefits

  • Sustained energy without tolerance

    EVIDENCEB

    Taylor 2016.

  • Mental clarity

    EVIDENCEB

    Multiple sponsor-funded RCTs.

Side effects

  • Mild headache (high dose)uncommonmild

Where to buy

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