stimulantEVIDENCEBUSUnscheduled
Sulbutiamine
Synthetic derivative of vitamin B1 (thiamine) developed in Japan in the 1960s. Lipophilic — crosses BBB. Used for fatigue and mild mood support.
Dose range200–600mg
Half-life5h
Onset45min
Safety4/5medium evidence base
Mechanism of action
Two thiamine molecules linked by disulfide bridge. Crosses BBB readily, raising brain thiamine. Increases dopamine D1 in PFC.
Benefits
Asthenia / chronic fatigue
EVIDENCEBTiev et al. 1999.
Mood and motivation
EVIDENCECAnecdotal + small studies.
Side effects
- Tolerance with daily usecommonmild
- Mild skin rashraremild
Where to buy
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