neuroprotectiveEVIDENCEBUSOTC
Spermidine
Polyamine found in wheat germ, aged cheese, soybeans. Induces autophagy — cellular cleanup linked to longevity.
Dose range1–5mg
Half-life—h
Onset—min
Safety5/5medium evidence base
Mechanism of action
Induces autophagy via inhibition of histone acetyltransferases. Promotes mitophagy. Cardioprotective.
Benefits
All-cause mortality reduction
EVIDENCEBKiechl 2018 prospective.
Cognitive aging
EVIDENCEBWirth 2018.
Side effects
- Mild GI upset (high dose)uncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Double Wood Supplements 4.4 | Spermidine, 30ct (1mg) | 30 × 1mg | $29.99 | $1.00 | Buy |