vitaminEVIDENCEAUSOTC
SAMe
aka S-adenosylmethionine · SAM-e
S-adenosylmethionine — universal methyl donor. Studied for depression, joint health, and liver support.
Dose range400–1600mg
Half-life—h
Onset—min
Safety4/5high evidence base
Mechanism of action
Direct methyl donor for ~100 methylation reactions including neurotransmitter synthesis (dopamine, norepinephrine, serotonin).
Benefits
Major depressive disorder
EVIDENCEAWilliams 2010 meta-analysis.
Osteoarthritis
EVIDENCEASoeken 2002.
Side effects
- Insomnia (if dosed late)commonmild
- Mania (in bipolar)raresevere
Where to buy
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