adaptogenEVIDENCEAUSOTC
Saffron
aka Crocus sativus
Crocus stigma — most expensive spice. Increasingly evidence-based antidepressant comparable to SSRIs at low doses.
Dose range28–30mg
Half-life—h
Onset—min
Safety4/5high evidence base
Mechanism of action
Crocin and safranal inhibit serotonin and dopamine reuptake. Antioxidant.
Benefits
Mild-to-moderate depression
EVIDENCEAMultiple meta-analyses non-inferior to fluoxetine.
ADHD symptoms
EVIDENCEBBaziar 2019; Khaksarian 2021.
Premenstrual syndrome
EVIDENCEBMultiple RCTs.
Side effects
- Mild dry mouthuncommonmild
- Reduced appetiteuncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | Saffron Extract Capsules, 60ct (28mg) | 60 × 28mg | $29.99 | $0.50 | Buy |
| Double Wood Supplements 4.4 | Saffron Extract, 60ct (28mg) | 60 × 28mg | $19.99 | $0.33 | Buy |