cholinergicEVIDENCEBUSOTC
Phosphatidylserine (PS)
aka PS · Sharp-PS
Phospholipid concentrated in brain cell membranes. Supports membrane fluidity and stress response.
Dose range100–300mg
Half-life12h
Onset—min
Safety5/5high evidence base
Mechanism of action
Structural phospholipid component of neuronal membranes. Modulates cortisol response to stress. Supports ACh and dopamine signaling.
Benefits
Memory in age-related cognitive decline
EVIDENCEBMultiple RCTs.
Reduced cortisol from exercise stress
EVIDENCEBStarks et al. 2008.
Side effects
- Insomnia (if dosed late)uncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | Sharp-PS Phosphatidylserine, 60ct (100mg) | 60 × 100mg | $29.99 | $0.50 | Buy |
| Double Wood Supplements 4.4 | Phosphatidylserine, 60ct (100mg) | 60 × 100mg | $19.99 | $0.33 | Buy |