nootropics.com
SubstancesStacksToolsCompareVendorsGuidesBuild a stack
Back to library
stimulantEVIDENCEAUSSchedule IV

Modafinil

aka Provigil · Modalert · Modvigil · Alertec

Eugeroic developed for narcolepsy; one of the most popular prescription cognitive enhancers. Sustained alertness without traditional stimulant side effects.

Dose range100–200mg
Half-life14h
Onset45min
Safety3/5high evidence base

Mechanism of action

Inhibits dopamine reuptake via DAT. Modulates orexin/hypocretin, histamine, norepinephrine. Enhances glutamate release.

Benefits

  • Sustained wakefulness 12-15h

    EVIDENCEA

    Multiple RCTs.

  • Working memory and executive function

    EVIDENCEA

    Battleday & Brem 2015 (24 studies).

Side effects

  • Headachecommonmoderate
  • Anxiety / nervousnessuncommonmoderate
  • Stevens-Johnson Syndromeraresevere
  • Reduces hormonal contraceptive efficacycommonmoderate

Where to buy

Affiliate links
No vendor products listed yet. Vendors — list a product.