neuroprotectiveEVIDENCECUSResearch chemical

Mexidol (Emoxypine)

aka Emoxypine succinate · 2-Ethyl-6-methyl-3-hydroxypyridine succinate

Russian prescription antioxidant and anti-anxiety compound. Membrane stabiliser used for cerebrovascular and anxiety conditions.

Dose range125–500mg

Half-life—h

Onset—min

Safety4/5low evidence base

Mechanism of action

Antioxidant through scavenging reactive oxygen species and stabilising membrane lipid bilayer. Modulates GABA receptor signalling for anxiolytic effect. Improves cerebral microcirculation. The combined mechanism produces anxiolytic and cognitive effects without sedation.

History

Mexidol was developed in the Soviet Union in the 1980s and is approved as a prescription drug in Russia and several former Soviet states for cerebrovascular disorders, anxiety, and alcohol withdrawal. Western availability is limited; the compound has a substantial Russian clinical literature but minimal Western evaluation. Unscheduled in some Western jurisdictions; not available as a regulated product.

Benefits

Anxiolytic effect
EVIDENCEC
Russian clinical use.
Cerebrovascular function
EVIDENCEC
Russian trials.

Side effects

Mild drowsinessuncommonmild
GI upsetuncommonmild

Cited research

Mexidol antioxidant mechanism (Devyatkina)1993
PMID 8049820 ↗
Emoxypine for ischemic stroke: Russian clinical trial2006
PMID 16553212 ↗

Where to buy

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Vendor	Product	Size	Price	Per unit
Nootropics DepotFeatured 4.8	Mexidol (Emoxypine) — Nootropics Depot	—	See vendor	—	Shop Ad
Life Extension 4.3	Mexidol (Emoxypine) — Life Extension	—	See vendor	—	Shop Ad
Double Wood Supplements 4.4	Mexidol (Emoxypine) — Double Wood	—	See vendor	—	Shop Ad
Amazon Marketplace 3.5	Mexidol (Emoxypine) — Amazon	—	See vendor	—	Shop Ad

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