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neuroprotectiveEVIDENCEAUSRx

Metformin

Anti-diabetic medication studied for longevity. AMPK activator. Glucose normalization.

Dose range500–2000mg
Half-life—h
Onset—min
Safety4/5high evidence base

Mechanism of action

Activates AMPK. Inhibits hepatic gluconeogenesis. Reduces inflammation.

Benefits

  • Type 2 diabetes prevention/management

    EVIDENCEA

    Universally accepted.

  • Possible all-cause mortality reduction

    EVIDENCEC

    Bannister 2014.

Side effects

  • GI upset (often resolves)commonmoderate
  • B12 depletion (chronic)commonmoderate
  • Lactic acidosis (rare)raresevere

Where to buy

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