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neuroprotectiveEVIDENCEAUSOTC

Melatonin

Pineal hormone regulating circadian rhythm. Low doses (0.3-1mg) often outperform higher doses for sleep.

Dose range0.3–3mg
Half-life1h
Onset30min
Safety5/5high evidence base

Mechanism of action

Endogenous circadian signal. Binds MT1/MT2 receptors. Lower doses (0.3mg) better match physiological levels.

Benefits

  • Sleep onset

    EVIDENCEA

    Multiple meta-analyses.

  • Jet lag

    EVIDENCEA

    Herxheimer 2009 Cochrane.

  • Antioxidant

    EVIDENCEB

    Mechanism + animal.

Side effects

  • Morning grogginess (high dose)commonmild
  • Vivid dreamscommonmild

Where to buy

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