vitaminEVIDENCECUSOTC
Lithium Orotate
Low-dose lithium for mood support. Sub-prescription doses studied for mild mood stabilization.
Dose range1–20mg
Half-life—h
Onset—min
Safety3/5low evidence base
Mechanism of action
Inhibits GSK-3β. Increases BDNF. Modulates inotropic glutamate. Low-dose orotate form is much lower than prescription carbonate.
Benefits
Mood support (anecdotal + low-dose studies)
EVIDENCECSartori 1986.
Neuroprotection via BDNF
EVIDENCECMechanism + animal models.
Side effects
- Thyroid impact (high dose)uncommonmoderate
- Tremor (high dose)uncommonmoderate
Where to buy
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