adaptogenEVIDENCEBUSOTC
Lion's Mane
aka Hericium erinaceus · Yamabushitake
Medicinal mushroom (Hericium erinaceus) that stimulates Nerve Growth Factor (NGF) production. Supports neurogenesis and myelin.
Dose range500–3000mg
Half-life8h
Onset—min
Safety5/5medium evidence base
Mechanism of action
Hericenones and erinacines stimulate NGF synthesis. Crosses BBB. Supports peripheral nerve regeneration.
Benefits
NGF upregulation
EVIDENCEBMori et al. 2008.
Mild cognitive impairment
EVIDENCEBMori et al. 2009 RCT.
Anxiety and depression
EVIDENCEBNagano et al. 2010.
Side effects
- Itching (rare allergic)raremild
- GI upsetuncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | Lion's Mane Mushroom 8:1 Dual Extract, 60ct (500mg) | 60 × 500mg | $29.99 | $0.50 | Buy |
| Double Wood Supplements 4.4 | Lion's Mane Mushroom Capsules, 90ct (500mg) | 90 × 500mg | $19.99 | $0.22 | Buy |