cholinergicEVIDENCEAUSOTC
Huperzine A
aka HupA · Selagine
Potent acetylcholinesterase inhibitor derived from Chinese club moss. Studied for Alzheimer's treatment in China.
Dose range0.05–0.2mg
Half-life12h
Onset60min
Safety3/5high evidence base
Mechanism of action
Reversibly inhibits acetylcholinesterase. NMDA receptor antagonist, providing neuroprotection. Promotes hippocampal neurogenesis.
Benefits
Memory in Alzheimer's
EVIDENCEAWang et al. 2009 Cochrane review of 6 RCTs.
Learning in healthy individuals
EVIDENCEBSeveral small RCTs.
Side effects
- Nausea, vomitinguncommonmoderate
- Muscle twitching/crampinguncommonmoderate
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | Huperzine A Capsules, 90ct (200mcg) | 90 | $14.99 | $0.17 | Buy |
| Pure Nootropics 4.5 | Huperzine A Capsules, 60ct (200mcg) | 60 | $12.99 | $0.22 | Buy |
| Double Wood Supplements 4.4 | Huperzine A Capsules, 120ct (200mcg) | 120 | $14.99 | $0.12 | Buy |