amino-acidEVIDENCECUSOTC
GABA
Primary inhibitory neurotransmitter. Oral GABA's BBB penetration debated; effects largely peripheral.
Dose range100–750mg
Half-life—h
Onset—min
Safety4/5low evidence base
Mechanism of action
Endogenous inhibitory neurotransmitter at GABA-A and GABA-B receptors. Oral GABA poorly crosses BBB but may act on enteric nervous system / vagus.
Benefits
Subjective relaxation / stress reduction
EVIDENCECAbdou 2006.
Side effects
- Tingling / paresthesiacommonmild
- Headacheuncommonmild
Where to buy
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