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cholinergicEVIDENCECUSOTC

DMAE

aka Dimethylaminoethanol · Deanol

Dimethylaminoethanol — a choline precursor with mild stimulant effects. Found naturally in sardines and anchovies.

Dose range100–500mg
Half-life4h
Onsetmin
Safety4/5low evidence base

Mechanism of action

Crosses BBB and is metabolized to choline, supporting ACh synthesis. May also reduce lipofuscin accumulation.

Benefits

  • Mild focus enhancement

    EVIDENCEC

    Older European clinical use.

  • ADHD symptoms (historical)

    EVIDENCEC

    Studied as Deanol decades ago.

Side effects

  • Headachecommonmild
  • Insomniauncommonmild

Where to buy

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