amino-acidEVIDENCEBUSOTC
Dihydromyricetin (DHM)
aka DHM · Ampelopsin
Flavonoid from Hovenia dulcis (Japanese raisin tree). Popular for hangover prevention and reducing alcohol-induced GABA-A downregulation.
Dose range300–600mg
Half-life—h
Onset—min
Safety4/5medium evidence base
Mechanism of action
Positive allosteric modulator of GABA-A at the benzodiazepine site. Reverses ethanol's GABA effects acutely.
Benefits
Reduces alcohol intoxication symptoms
EVIDENCEBAnimal models; small human studies.
Side effects
- Mild GI upsetuncommonmild
Where to buy
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