neuroprotectiveEVIDENCEBUSOTC
Apigenin
Flavonoid found in chamomile, parsley, and celery. Popularized by Dr. Andrew Huberman for sleep and CD38 inhibition.
Dose range50–100mg
Half-life—h
Onset—min
Safety5/5low evidence base
Mechanism of action
GABA-A partial agonist (anxiolytic effect). CD38 inhibitor (NAD+ preservation). Antioxidant.
Benefits
Sleep quality / anxiety
EVIDENCEBSmall RCTs in chamomile extract.
CD38 inhibition / NAD+ preservation
EVIDENCECMechanism + animal.
Side effects
- Mild sedation if dosed in AMuncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Double Wood Supplements 4.4 | Apigenin, 60ct (50mg) | 60 × 50mg | $19.99 | $0.33 | Buy |