cholinergicEVIDENCEAUSOTC
Alpha-GPC
aka L-Alpha Glycerylphosphorylcholine · Choline Alfoscerate · GPC
Highly bioavailable choline compound that efficiently delivers choline across the blood-brain barrier.
Dose range300–600mg
Half-life6h
Onset30min
Safety5/5high evidence base
Mechanism of action
Cleaved into choline and glycerophosphate. Choline serves as acetylcholine precursor. Glycerophosphate supports phospholipid membranes.
Benefits
Memory and learning via increased ACh
EVIDENCEAMultiple human RCTs.
Cognitive function in Alzheimer's
EVIDENCEADe Jesus Moreno, 2003.
Growth hormone secretion
EVIDENCEBKawamura et al. 2012.
Power output in athletes
EVIDENCEBZiegenfuss et al. 2008.
Side effects
- Headache (high doses)uncommonmild
- Fishy body odor (high doses)uncommonmild
Where to buy
Affiliate links| Vendor | Product | Size | Price | Per unit | |
|---|---|---|---|---|---|
| Nootropics DepotFeatured 4.8 | Alpha-GPC Capsules, 60ct (300mg) | 60 × 300mg | $24.99 | $0.42 | Buy |
| Double Wood Supplements 4.4 | Alpha GPC Capsules, 60ct (300mg) | 60 × 300mg | $17.99 | $0.30 | Buy |
| Pure Nootropics 4.5 | Alpha-GPC Capsules, 60ct (300mg) | 60 × 300mg | $24.99 | $0.42 | Buy |