amino-acidEVIDENCEBUSOTC
Agmatine Sulfate
Decarboxylation product of L-arginine. Modulates NMDA, α2-adrenergic, and imidazoline receptors.
Dose range500–2500mg
Half-life2h
Onset—min
Safety4/5low evidence base
Mechanism of action
NMDA receptor antagonist (low-affinity). Modulates nitric oxide synthase. Potentiates analgesics.
Benefits
Neuropathic pain modulation
EVIDENCEBSmall RCTs.
Anxiolytic + antidepressant (animal models)
EVIDENCECMechanistic.
Side effects
- Lowered blood pressurecommonmild
- GI discomfortcommonmild
Where to buy
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