neuroprotectiveEVIDENCEAUSOTC

Aged Garlic Extract

aka Kyolic · AGE

Aged garlic (Kyolic) with reduced allicin and increased S-allylcysteine. Cardiovascular and immune evidence.

Dose range600–2400mg

Half-life—h

Onset—min

Safety5/5high evidence base

Mechanism of action

Aged garlic conversion produces S-allylcysteine (SAC) and reduces volatile allicin. SAC has antioxidant and cardiovascular protective effects with much better tolerability than raw garlic. Modulates nitric oxide synthesis; reduces LDL oxidation; modulates platelet aggregation.

History

Garlic has been used medicinally for millennia. Aged garlic extract was developed in Japan in the 1960s — slow fermentation of fresh garlic over 18-24 months converts the volatile allicin to more stable, water-soluble compounds. The branded Kyolic form has the largest evidence base. Multiple cardiovascular trials support use.

Benefits

Blood pressure reduction
EVIDENCEA
Multiple meta-analyses.
LDL cholesterol
EVIDENCEB
Multiple RCTs.
Cardiovascular biomarkers
EVIDENCEA
Multiple trials.

Side effects

Garlic body odorcommonmild
GI upsetuncommonmild

Cited research

Aged garlic extract for hypertension: meta-analysis (Ried)2016
PMID 27444134 ↗
Aged garlic extract for cardiovascular markers (Budoff)2009
PMID 19620063 ↗
S-allylcysteine pharmacology review (Borek)2001
PMID 11451746 ↗

Where to buy

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Vendor	Product	Size	Price	Per unit
Nootropics DepotFeatured 4.8	Aged Garlic Extract — Nootropics Depot	—	See vendor	—	Shop Ad
Life Extension 4.3	Aged Garlic Extract — Life Extension	—	See vendor	—	Shop Ad
Double Wood Supplements 4.4	Aged Garlic Extract — Double Wood	—	See vendor	—	Shop Ad
Amazon Marketplace 3.5	Aged Garlic Extract — Amazon	—	See vendor	—	Shop Ad

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