Comparison
Magnesium L-Threonate vs Fisetin
Magnesium L-Threonate
MIT-developed magnesium that crosses the blood-brain barrier. Shown to enhance synaptic density and reduce 'brain age'.
Fisetin
Flavonoid found in strawberries. Senolytic, selectively clears senescent cells. Promising longevity intervention.
| Field | Magnesium L-Threonate | Fisetin |
|---|---|---|
| Category | neuroprotective | neuroprotective |
| Dose range | 1000–2000mg | 100–500mg |
| Half-life | 6h | – |
| Onset | – | – |
| Evidence | EVIDENCEB | EVIDENCEB |
| Safety | ●●●●● | ●●●●○ |
| Legal (US) | USOTC | USOTC |
| PubMed refs | 90 | 1700 |
The comparison in plain English
Auto-generated from dataMagnesium L-Threonate and Fisetin are both in the neuroprotective category respectively. Magnesium L-Threonate MIT-developed magnesium that crosses the blood-brain barrier. Fisetin Flavonoid found in strawberries.
Bottom line
Magnesium L-Threonate (evidence B, safety 5/5) matches the evidence base of Fisetin (evidence B, safety 4/5). Magnesium L-Threonate has the slightly cleaner safety profile. For users new to either, the higher-evidence option is the safer first try.
Choose Magnesium L-Threonate if
Magnesium L-Threonate is the better fit when your goal aligns with its mechanism (L-threonate is a sugar-acid carrier that uniquely enables magnesium to cross the blood-brain barrier in meaningful quantities, most oral magnesium forms (oxide, citrate, glycinate) raise serum magnesium but not central magnesium) and the dose range (1000–2000mg) suits your protocol. Half-life is 6h.
Choose Fisetin if
Fisetin is the better fit when your goal aligns with its mechanism (Senolytic activity, selectively induces apoptosis in senescent cells (cells that have stopped dividing but remain metabolically active and inflammatory)) and the dose range (100–500mg) suits your protocol. Half-life is –h.