PRL-8-53: Is This Powerful Memory-Boosting Nootropic Right for You?

Purported to be a powerful nootropic drug that can dramatically boost memory formation, retention, and cognition, PRL-8-53 has become one of the most promising nootropics on the market. Scores of users rely on PRL-8-53 to improve their memory while boosting cognition, as well.

While PRL-8-53 has been around since the mid-70s, research is relatively limited, and there’s still a lot we’ve yet to discover about this drug. But, there’s also a lot that we already know. Today, we’ll take a look at everything you need to know about this drug, including what it is, how it works, benefits, dosage information, and side effects.

What is PRL-8-53?

PRL-8-53’s name may be a bit obtuse, but it’s certainly easier to say than the drugs actual name; methyl 3-(2-(benzyl (methyl) amino) ethyl) benzoate. This supplement was discovered by professor Nikolaus Hensl at Creighton University in the early ‘70s, and it was first patented in 1974.

PRL-8-53 is derived from benzoic acid, which can be found in many of our favorite foods, such as dairy products, berries, and some plants.

While there isn’t a large body of research to support the use of PRL-8-53, neurohackers have found it to be a powerful nootropic supplement that’s capable of improving memory function as well as cognition.

How does PRL-8-53 work?

When it comes to how PRL-8-53 works, that’s the million-dollar question. While preliminary research conducted in the ‘70s was promising, this supplement has largely taken a back burner to other new substances which have received more comprehensive testing. Since there have only been a few studies on the topic, we only have a preliminary understanding of how PRL-8-53 works.

Researchers believe that PRL-8-53 displays cholinergic properties and that it increases acetylcholine activity, which is a neurotransmitter that plays a critical role in memory and cognition. It looks like this supplement may also increase dopamine levels in the brain, which are connected to our memory function, motivation, and fatigue levels.

PRL-8-53 also seems to inhibit serotonin production, which may increase feelings of anxiety, depression, or insomnia. While heightened levels of dopamine combined with lowered levels of serotonin may lead to impulsive aggressive disorders, human trials did not reveal such symptoms or side effects.

PRL-8-53 benefits

The primary benefits of PRL-8-53 supplementation are improved memory and improved cognitive function.

The one human study of PRL-8-53 involved testing subjects based on their ability to correctly recall the order of 6-8 words in a word recollection test.

While those who scored the highest on the test in the control group didn’t seem to experience a vast improvement in their test scores on PRL-8-53, those from the control group who initially scored lower on the test showed a dramatic improvement in their abilities after PRL-8-53 supplementation.

Those who scored well in both the placebo group and the PRL-8-53 group did see a slight improvement in their scores after PRL-8-53 supplementation; it wasn’t deemed statistically significant.

The results were especially profound when looking at the improvements in test scores of individuals who were over the age of 30. This test suggests that those who have difficulty with memory retention stand to enjoy the most significant benefits of PRL-8-53, especially those over 30 years old.

A second experiment conducted by the drug’s creator, Dr. Nikolaus Hansl claimed that PRL-8-53 supplementation improved cognitive performance in test subjects as well, but the findings from that study are unpublished. Within that same study, Dr. Hansl also concluded that verbal proficiency and pattern analysis was also improved by PRL-8-53.

Of course, it’s difficult to conclude an unpublished study. But, if the thoughts of the nootropic community are of any consolation to you, then PRL-8-53 appears to be a powerful nootropic that indeed does offer powerful memory and cognitive benefits.

PRL-8-53 dosage

Like all of the other information about PRL-8-53, dosage information is quite limited. Most users take their cues from the one published study on PRL-8-53, which administered 5mg doses of the drug. After developing a better understanding of how they react to PRL-8-53, users often up their dosage to 10-20mg per day.

The patent information for this supplement states that the ideal dosage range per kilogram of body weight is .1-4mg. That’s an incredible wide dosage range. For example, someone who is 5’10 and weighs 80kg would have an ideal dosage range of 8-320mg per day, which is an incredibly wide variance in dosage.

While there’s no evidence that higher doses of PRL-8-53 are especially dangerous (the drug exhibited an incredibly high LD50 in animal tests, with a dose of 860mg/kg of bodyweight proving lethal) there’s also nothing to suggest a therapeutic dosage range beyond the 5-20mg range.

Ignoring the dosage information associated with the patent, we suggest getting started with a dosage of 5mg and adjusting your dosage up or down as needed, depending on the effect that is produced.

How to take PRL-8-53

In the published studies, Dr. Hansl’s team hinted that other administrations of PRL-8-53 might prove to be more effective, but only oral supplementation was studied. For that reason, we recommend sticking with an oral dose of this supplement.

PRL-8-53 is most typically available as a power, and it’s sold in 1-5-gram jars. Most users will weigh out their dosage and swallow it, add it to a drink, or package it inside of a capsule for easier consumption.

Popular PRL-8-53 stacks

Different nootropics possess many different benefits that may positively affect areas, including learning, cognition, focus, alertness, memory formation, memory retention, and more. While these drugs may provide one or two benefits on their own, there is often a synergistic effect between different nootropics when they are taken together.

The idea in place is that the stacked supplement is greater than the sum of its parts, and it’s a technique that many within the community rely on to achieve the maximum therapeutic benefits from different nootropics.

As PRL-8-53 is a relatively unknown nootropic with only a limited body of research to support its usage, it’s harder to say what this supplement stacks best with. However, many people find that PRL-8-53 can be a good addition to a well-formulated stack.

Other relatively innocuous supplements such as vitamin B12, Alpha-GPC, Memantine, Sunifiram, Semax, or N-acetyl appear to be solid options for stacking with PRL-8-53.

Keep in mind that since we have such a limited understanding of how PRL-8-53 works, and the substances that it may interact with, it’s hard to say with any certainty if these or any other stacks are effective, or even safe. For this reason, we don’t recommend including PRL-8-53 in your stack.

How do users feel about PRL-8-53

As with other research chemicals, anecdotal evidence is often the most reliable indicator of whether or not a particular supplement produces the desired effect.

PRL-8-53 does seem promising. Many users in the Reddit nootropic community reported significant memory improvement with dosages in the 10-20mg range and were able to recall key themes, concepts, and figures with ease. They also had an easier time reiterating those concepts and themes verbally.

Some users have suggested that their reaction times when playing games were also improved, and they were more able to focus on the task at hand.

PRL-8-53 side effects

In human studies, PRL-8-53 was tolerated quite well, and the test subjects presented no side effects at all. In animal studies, high doses of PRL-8-53 appeared to depress motor function. Since there hasn’t been much research on this supplement, it’s difficult to pinpoint any applicable side effects beyond the anecdotal evidence that’s been provided by the nootropic community.

Those who take PRL-8-53 mirror the sentiment that this nootropic is well-tolerated and presents few side effects if any. Those who do experience side effects find them to be quite mild, and the most common side effect is a mild headache. Some users have noted that this supplement doesn’t interact well with antihistamines.

As with all supplements, you should closely monitor how your body responds to low dosages before moving on to a fully therapeutic dose.
Keep in Mind
While PRL-8-53 seems to be a very safe nootropic supplement, it’s important to consider perspective: all research of this supplement has been conducted by the patent holder, and the research that has been published is quite limited.

As a research chemical, there is currently no accepted therapeutic benefit to this supplement, and it’s possible that there are dangers associated with PRL-8-53 that we have yet to realize. For this reason, we suggest taking this supplement with caution and developing a full understanding of its effects before upping your dosage or stacking this supplement with other nootropics.


As one of the most promising memory-enhancing nootropics on the market, PRL-8-53 is believed to be one of the best supplements you can add to your regimen by many members of the nootropic community.

If you’re looking to boost your memory and cognitive function, we recommend looking into this supplement. But, considering the lack of research on this supplement, we recommend treading lightly until you have a more complete understanding of how your body gets along with PRL-8-53.